June 10, 2022
CD Genomics, a world-leading genomics services company, today announced that members of its management team will participate in the BIO International Convention......
April 9, 2021
NEW YORK – A new sequencing study suggests gut microbial communities are individualized and relatively stable over time, though the extent of that genetic stability varies somewhat with the microbial species considered. Researchers from the Netherlands and Israel did metagenomic sequencing on fecal samples from......
March 26, 2021
NEW YORK – An international group of researchers has shown that low-coverage sequencing can effectively identify novel variants in the genomes of individuals from populations that are currently underrepresented in genomic databases, and can help overcome challenges presented by common genotyping arrays.......
March 11, 2021
Reconstructing the sequence of circular RNAs (circRNAs) from short RNA sequencing reads has proved challenging given the similarity of circRNAs and their corresponding linear messenger RNAs. Previous sequencing methods were unable to achieve high-throughput detection of full-length circRNAs. Here we describe a protocol for......
March 3, 2021
The genomes, available through repositories in the US, Europe, and Japan, include data from Pacific Biosciences' HiFi reads, Oxford Nanopore Technologies' ultralong reads, and Bionano Genomics' optical mapping. Hi-C data for all 30 samples generated with Dovetail Genomics' Omni-C kits will be released this month.......
February 19, 2021
Multimodal single-cell RNA sequencing enables the precise mapping of transcriptional and phenotypic features of cellular differentiation states but does not allow for simultaneous integration of critical posttranslational modification data. Here, we describe SUrface-protein Glycan and RNA-seq (SUGAR-seq), a method that......
February 18, 2021
Researchers have developed a new integrated genetic/epigenetic DNA-sequencing protocol known as MultiMMR that can identify the presence and cause of mismatch repair (MMR) deficiency in a single test from a small sample of DNA in colon, endometrial and other cancers. This alternative to complex, multi-step testing workflows can also......
February 17, 2021
In 2013, DNA from a horse that lived sometime between 560,000 and 780,000 years ago was sequenced. It was the most ancient DNA sample ever analysed. But that record has just been smashed by van der Valk and colleagues, writing in Nature. The authors retrieved DNA from the molars of three......
February 2, 2021
5-Methylcytosine (5mC) is an important type of epigenetic modification. Bisulfite sequencing (BS-seq) has limitations, such as severe DNA degradation. Using single molecule real-time sequencing, we developed a methodology to directly examine 5mC. This approach holistically......
January 6, 2021
Researchers have successfully used a DNA-editing technique to extend the lifespan of mice with the genetic variation associated with progeria, a rare genetic disease that causes extreme premature aging in children and can significantly shorten their life expectancy. The study was......
December 31, 2019
The pantropical plant genus Dalbergia comprises approximately 250 species, most of which have a high economic and ecological value. However, these species are among the most threatened due to illegal logging and the timber trade. To enforce protective legislation and ensure effective conservation of......
December 20, 2019
Our most popular news story – the new blood test that can detect multiple cancer types with a high degree of accuracy. The test focused on analysing epigenetic markers in cancer DNA present in the blood, with trials showing a 99.4% specificity when using the test. It can also detect......
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