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Plasmid-mediated gene transfer plays an important role not only in the mobilization and dissemination of antibiotic resistance and virulence genes but also in the evolution of microbial populations. CD Genomics offers complete plasmid DNA sequencing service and improved bioinformatics pipelines that deliver reliable and accurate data.
Bipolar Disorder (BD) is a chronic brain disorder characterized by recurrent episodes of mania and depression, and SYNES1 is considered a locus loci for BD. CD Genomics offers an effective and affordable targeted region sequencing for accurately detecting genomic variants in targeted genes/regions.
Before this study, it was not known whether circular DNA tumor viruses, like Epstein-Barr virus (EBV) and Kaposi’s sarcoma herpesvirus (KSHV) expressed circRNAs. CD Genomics offers circRNA sequencing for checking the presence of circRNAs in EBV and KSHV tumors and cell lines cells, and characterizing these circRNAs produced by viruses.
In humans, KIAA1429, a homologue of D. melanogaster Virilizer (Vir), combined with METTL3, is required for m6A writer activity in mammals. CD Genomics offers a versatile method, whole genome sequencing, for detecting mutations in vir-1 mutant of Arabidopsis thaliana.
Preterm delivery is the major cause of perinatal morbidity and mortality. And the consumption of a high-fat diet can increase the rates of spontaneous preterm birth. However, the underlying mechanisms are still unclear. CD Genomics offers both 16S rRNA sequencing and RNA-seq to explore the association between high-fat diet and preterm birth.
The yeast strain ISA1307, isolated from a sparkling wine plant, was formerly considered the Zygosaccharomyces bailii species. However, whole-genome shotgun sequencing in this work indicates that the strain ISA1307 is an interspecies hybrid between Z. bailii and a closely related species.
The major constraints to cultivated peanut (Arachis hypogaea) are drought and fungal diseases. Two wild relatives of peanut harbor resistances to drought or fungal infection. CD Genomics offers global transcriptome analysis to identify genes involved in responses to biological processes such as fungal diseases and drought.
Several real-world projects, including CAR-T cell IL-4 regulation, phage genome comparison, mitochondrial genome assembly, and mouse RNA-seq analysis, demonstrate practical applications of bioinformatics in diverse research areas. CD Genomics offers customized transcriptome and multi-omics analysis to support gene discovery and interpretation across complex biological processes.
CAR-T cell approaches are limited by cell exhaustion, which impacts their effectiveness. Wild-type immune cells show resistance to exhaustion. CD Genomics offers RNA-seq, ATAC-seq, and CRISPR screening to explore gene expression and chromatin changes in immune system research.
ChIP-seq and RNA-seq were used to study gene regulation in ABCG2⁺ L3.6pl tumorspheres. ChIP-seq identified PHF5A and PHF14 co-binding sites, while RNA-seq revealed gene expression changes after KMT2A inhibition. CD Genomics provided full-service support to advance cancer stem cell research.