Long Read Sequencing for Industrial Microbiome

Utilization of cheap biomass resources is one of the important goals of industrial biotechnology. The traditional strategy is to use a single strain for microbial fermentation. However, inexpensive biomass often contains complex components and impurities that are difficult for individual microbes to utilize efficiently. CD Genomics provides long read sequencing solutions for studying microbial communities in the food, environmental, energy, chemical, and other industrial sectors to meet the global demand for new therapies, environmental remediation, and efficient chemical production.

Introduction to Industrial Microbiome

The industrial microbiome is the study of microbial communities with applications in food, environment, energy, chemical, and other industries. Microbial communities have been documented for thousands of years in traditional food applications such as vinegar, soy sauce, cheese, wine, bread, and kimchi. They have also been used and studied in biofuels (biogas, biohydrogen, ethanol, butanol, etc.), bio-based chemicals (1,3-propanediol), biomaterials (polyhydroxy fatty acid esters), and microbial communities. Microbial communities in the natural environment have many attractive properties such as compositional stability, functional robustness, broad substrate spectrum, and ability to perform complex tasks compared to those based on genetically engineered strains. Biotechnology has contributed significantly to improving the productivity and quality of chemical products and food. A particularly powerful approach in molecular tools is genome sequencing and the sequencing of individual genes and markers. Long read sequencing technology provides a unique approach to deoxyribonucleic acid (DNA) sequencing and allows very long DNA strands to be processed into long sequence reads. These long reads offer several advantages that can be used to improve industrial biotechnology and provide some unique DNA testing methods to identify the species origin of a food product or to detect the location of genetic modifications.

Fig. 1. The application of microbiome in industry, agriculture, health, and environment. (Zhang et al., 2020)

Solutions Offering at CD Genomics

As a leading provider of genomic research, CD Genomics offers long read sequencing solutions to analyze microbial communities in food, environmental, energy, chemical, and other industrial sectors. Industrial samples, especially those from environments such as fermenters or bioreactors, contain a wide range of microbial species. Our long read sequencing solutions can generate longer overlapping clusters, which help to distinguish between closely related species and strains, providing a more accurate overview of the microbial community.

CD Genomics also offers an extensive bioinformatics toolkit. Our team employs advanced algorithms and software to assemble, annotate, and analyze long read sequencing data. Whether it's classifying metagenomic data or identifying novel microbiomes associated with industry, our suite ensures that raw data is converted into actionable insights.

Applications

• Our Long Read Sequencing Solutions for Biorefineries

To meet the needs of sustained socio-economic development, industrial biotechnology for the economical conversion of renewable materials into chemicals and fuels has been developed as an alternative to the energy-intensive and polluting traditional chemical industry. Industrial microbiomes based on microbial communities can play an important role in biorefineries. CD Genomics offers long read sequencing technology to analyze microbiomes used in biorefineries to improve the efficiency of chemical production.

• Our Long Read Sequencing Solutions for Food Industry

Microbial contamination, as a major source of food contamination, poses a significant risk to food quality and safety, jeopardizing consumer health, and requires effective detection methods to monitor it. CD Genomics offers long read sequencing technology to analyze and characterize microorganisms in food at the genetic level, with high recognition speed and accuracy, fully meeting the requirements for rapid detection.

CD Genomics is committed to providing long read sequencing technologies to characterize complex industrial microbiomes for industrial advancement and food safety. If you have any questions, please feel free to contact us. We look forward to working with you on projects of interest.

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