Epigenomic Transcription Factor Binding Site Analysis

Transcription Factor Binding Sites (TFBSs) are proteins with DNA binding activity that are involved in the regulation of transcription. Generally, TFs modulate gene expression by binding to gene promoter regions or to distal regions called enhancers. Transcription factors (TFs) play a major role in the regulation of gene expression. Discovering the TFs which bind to the regulatory regions of each gene has been long‑term focus of research. CD Genomics provides you with a variety of epigenomic transcription factor binding site analysis service to meet your scientific research needs.

Specific Epigenomic Transcription Factor Binding Site Analysis Approaches We Offer

• CHIP-SEQ and related protocols can be used to identify transcription factor (TF) binding sites throughout the genome. This assay relies on antibodies specific to the protein of interest, so this method is able to identify the binding site of only one TF.
• CD Genomics uses ATAC-seq data that can be used to identify binding sites for all DNA binding proteins in parallel by what is called TF footprint analysis.
• In a TF footprint, narrow droplets in the chromatin accessibility signal are interpreted as protein binding sites. the identity of the TF can be indirectly inferred from the binding motif. cd Genomics combined with RNA-seq data, TF footprints can be used to study the combined effects of TF on gene expression in a very high throughput manner.

Service Highlights

• The key to the regulation of gene expression is the regulation of transcription initiation level.
• The prediction of transcription factor binding sites is an important part of the study of gene transcriptional regulation.
• Accurate prediction will help one to understand and study the spatiotemporal nature of transcriptional regulation of target genes by different transcription factors.

Service Process

Deliverables

• Related experimental results raw data
• Experimental report
• Data analysis
• Image and result analysis

Our Features

Why Choose Us?

CD Genomics is a professional epigenomic transcription factor binding site analysis technology provider, supporting a variety of sequencing services. We are able to perform individual tests at the most precise level, as well as design and complete a suite of services as a solution to the subject project. CD Genomics has accumulated years of quintessence in the field of epigenomic sequencing service, helping our clients accelerate drug discovery and development and improve the overall success rate of their projects. If you would like to know more about this service, please feel free to contact us.