Epigenomic Assays
There are many high-throughput assays for epigenomic analysis, and CD Genomics continues to develop new protocols. Our epigenomic analyses focus on DNA methylation, DNA binding proteins, histone modifications, chromatin accessibility, or 3D conformation of chromatin. To study the direct effect of the epigenome on gene expression, epigenomic measurements are often complemented with RNA sequencing experiments in the same setting. Single cell experiments, particularly single cell ATAC sequencing, are increasingly performed as a combined assay with single cell RNA sequencing. This produces gene expression and chromatin accessibility profiles from the same individual cells.
Specific Epigenomic Assays Approaches We Offer
- DNA Methylation
DNA methylation assays based on bisulfite-treated DNA are capable of identifying methylation events at the highest resolution. Such assays use next-generation sequencing (whole genome or simplified representative bisulfite sequencing) or microarrays.
- Transcription factor binding and histone modifications
Antibodies are used for the identification of DNA-binding proteins such as transcription factors and for the determination of chemical modifications to histones. ChIP sequencing is the most commonly used method, but you can also choose newer alternative methods with higher resolution. These include ChIP-exo, Chipmentation, CUT&RUN and CUT&Tag.
- Chromatin accessibility analysis
The gold standard assay for mapping open chromatin regions is ATAC sequencing. ATAC-seq has largely replaced previous methods such as DNase-seq and FAIRE-seq.
- Chromatin conformation
The importance of three-dimensional chromatin conformation has recently received special attention. Hi-C is the typical assay for the former, while ChIA-PET can be applied to the latter.
Service Process
Deliverables
- Related experimental results raw data
- Experimental report
- Data analysis
- Image and result analysis
Our Features
- CD Genomics will complete your project on time and efficiently. We have professional after-sales service.
- CD Genomics works with scientists from many biotechnology companies. We have extensive knowledge and experience to provide quality assurance services.
- CD Genomics has a proven, advanced epigenomic assays technology platform that is constantly being improved to ensure that we can provide accurate, sensitive, and rapid analytical results for our customers.
Why Choose Us?
CD Genomics is a professional epigenomic assays technology provider, supporting a variety of sequencing services. We are able to perform individual tests at the most precise level, as well as design and complete a suite of services as a solution to the subject project. CD Genomics has accumulated years of quintessence in the field of epigenomic assays service, helping our clients accelerate drug discovery and development and improve the overall success rate of their projects. If you would like to know more about this service, please feel free to contact us.