Thank you for visiting the CD Genomics Blog! Here, you will find articles on the latest advances in sequencing technology, biotech research developments, and technical introductions. Our blog helps researchers and professionals deepen their understanding and stay updated on industry trends.
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In the realm of modern biology, unlocking the complexities of genomes has been significantly propelled by next-generation sequencing (NGS) technologies. Among these, the sequencing-by-synthesis (SBS) chemistry, in tandem with the esteemed DRAGEN Bio-IT platform, stands out for its unparalleled accuracy in delivering whole genome sequencing (WGS) data. However, the quest for understanding the entirety of […]
The NextSeq Sequencing Systems from Illumina is a powerful and versatile system for high-throughput sequencing applications. It’s designed to deliver rapid and accurate results across various sequencing workflows, making it a popular choice for research, clinical, and applied genomics projects. This series is available in a variety of models Illumina NextSeq500, NextSeq550, NextSeq1000 and NextSeq […]
What is rRNA? Ribosomal RNA (rRNA) serves as the foundational framework of the ribosome, a vital organelle orchestrating protein synthesis. Unlike messenger RNA (mRNA), which carries genetic instructions for protein assembly, rRNA is a non-coding RNA that facilitates the actual process within the ribosome. Derived from ribosomal DNA (rDNA), rRNA collaborates with ribosomal proteins to construct […]
Pyrophosphate sequencing represents an innovative enzymatic cascade chemiluminescence sequencing method driven by four key enzymes: DNA polymerase, ATP sulfurylase, luciferase, and adenosine triphosphate bisphosphatase (apyrase). This cutting-edge technology enables real-time detection of biological light signals emitted during DNA synthesis, setting a groundbreaking precedent for simultaneous sequencing and synthesis. In the realm of early tumor screening […]
What is Exon? A coding sequence within a fragmented gene, an exon (expressed region) constitutes a vital segment of a eukaryotic gene. It remains conserved post-splicing and serves as the basis for protein expression during protein biosynthesis. These nucleotide sequences are present in both the initial transcription product and the mature RNA molecule. Genome encompasses […]
The study of population evolution relies on advanced genomic techniques like whole-genome resequencing or other sequencing methods. These technologies enable the acquisition of genomic data from diverse subpopulations within a species. By extracting extensive variant information such as single nucleotide polymorphisms (SNP), insertions/deletions (InDel), structural variations (SV), and copy number variations (CNV), researchers delve into […]
Science’s understanding of genetics primarily focuses on the alterations in gene expression caused by genetic sequence modifications, encompassing gene mutations, heterogeneous loss, and microsatellite instability. Contrastingly, epigenetics considers the changes in gene expression attributable to non-genomic sequence variations, such as DNA methylation and modifications in chromatin conformation. The broader field of epigenomics is dedicated to the genomic […]
What is Agrobacterium-Mediated Plant Transformation? Agrobacterium, a soil-dwelling bacterium, can chemotactically infect a wide array of dicotyledonous plants. Exploiting wounded areas of the plant, Agrobacterium induces the formation of crown gall tumors or hairy roots. Within Agrobacterium‘s Ti and Ri plasmids resides a crucial fragment of transfer DNA known as T-DNA. This T-DNA has the remarkable capability […]
Overview of HLA Human leukocyte antigen (HLA) molecules are essential components of the immune system, playing a crucial role in activating antitumor immune responses through their interactions with T cell receptors (TCRs). HLA molecules are a class of glycoproteins composed of an alpha-heavy chain and a beta-light chain that are non-covalently bound. The structure of […]
Ten years ago, clinicians at several hospitals across the United States began sequencing the genomes of seemingly healthy infants in an attempt to understand how this technology would be able to detect recessive genetic disorders that would not be detected by conventional newborn blood tests. Recently, a team of researchers from BabySeq, the world’s first […]
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