What Is 16S rRNA? The 16S rRNA (16S ribosomal RNA) is a constituent component of the 30S subunit in prokaryotic ribosomes. The “S” in 16S pertains to the Svedberg unit, a measure that reflects the sedimentation rate of large molecules in a centrifugal field – the higher the value, the larger the molecule. The 16S rRNA gene […]
What is rRNA? Ribosomal RNA (rRNA) serves as the foundational framework of the ribosome, a vital organelle orchestrating protein synthesis. Unlike messenger RNA (mRNA), which carries genetic instructions for protein assembly, rRNA is a non-coding RNA that facilitates the actual process within the ribosome. Derived from ribosomal DNA (rDNA), rRNA collaborates with ribosomal proteins to construct […]
In recent years, TCR sequencing has become a vital area of research for investigating the structure and distribution of T cell receptors. The TCR, also known as the T cell receptor, is the fundamental component used by T cells to recognize antigens, stimulate T cell activation, and promote proliferation. TCR sequencing is essential in various research […]
Introduction of CRISPR technology In recent years, the field of genetic analysis has witnessed a groundbreaking advancement with the emergence of CRISPR sequencing. While CRISPR-Cas9 is well-known for its gene-editing capabilities, CRISPR sequencing harnesses the power of CRISPR technology to revolutionize our understanding of the genome. This blog post explores how CRISPR sequencing is transforming genetic […]
The use of PD-1/PD-L1 inhibitors has significantly improved overall survival in a subset of non-small cell lung cancer (NSCLC) patients, but only about 20% of patients respond to treatment. Identifying predictors of response is crucial to improve patient selection for immunotherapy. However, current understanding of relevant predictors is limited by the lack of large, multi-omic […]
In the realm of molecular biology research, there exist two oft-confounded methodologies used with regularity: genotyping and DNA sequencing. Despite their seeming synonymy, these methods differ considerably regarding their impact on research outcomes and applications. This blog post endeavors to elucidate the contrasts between genotyping and DNA sequencing, while exploring their respective benefits and drawbacks. […]
Introduction to Ribosome Profiling Ribosome-profiling techniques were developed in response to the importance of measuring gene expression at the translational level. Ribosome profiling is a direct technique for determining the precise mRNA region read by the ribosome and for directly examining the transcripts associated with the translation machinery. Ribosome profiling is a cellular snapshot of […]
Introduction to Population Evolution A population, also known as a species, is a group of individuals who can all interbreed. The collection of these genes is known as a gene pool because these individuals can share genes and pass on combinations of genes to the next generation. Only populations, not individuals, go through the evolutionary […]
Introduction to SARS-COV-2 In December 2019, the new severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) started and has enveloped the world in an unparalleled global pandemic. The clinical features of COVID-19 patients are comparable during the 2002-2003 outbreak of SARS-CoV-1, which caused more than 8,000 cases reported and about 800 deaths. As such, human SARS-CoV-2 […]
Genome-wide association study (GWAS) is a kind of method to detect all or most of the genes among different individuals in specific species and to understand the genetic variation between different individuals. Many susceptibility genes and loci have been found in colorectal cancer using the GWAS method, but there are still many unknown susceptibility genes […]
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