Population Genetics: Definition Population genetics is the study of the genetic makeup of biological populations, as well as the variations in genetic makeup that occur as a result of various factors, such as natural selection Population geneticists, work toward their objectives by creating abstract mathematical models of gene frequency dynamics, attempting to deduce conclusions from […]
The most powerful approach to scan for unspecific germline variations, somatic mutations, and structural variants is high-throughput sequencing. Whole-genome sequencing, exome sequencing, and targeted region sequencing are three of the most common sequencing concepts in DNA sequencing. While highly useful, in different aspects of data collection, computation time, and variant detection precision, sequencing data creates […]
The transcriptome is the collection of all RNA transcribed by an individual or a population of cells at a certain biological state. The studies into transcriptome focus on mRNAs and non-coding RNAs (ncRNAs), which encode various proteins and act as cellular regulators respectively. Transcriptomic studies interpret gene function and gene structure in a holistic view, […]
Emerging infectious diseases have the potential to impose enormous mortality, morbidity, and economic burdens on humans. Tracking the spread of infectious diseases to help control them has traditionally relied on the analysis of case data collected during the course of an epidemic or pandemic. Over the last few decades, there has been a few cases […]
Amplicons Definition In molecular biology, amplicons represent DNA or RNA fragments that are the source and/or product of amplification or replication events. They can be naturally formed through gene duplication. Natural gene duplication plays a crucial role in genomic evolution. In this context, an amplicon refers to a section of chromosomal DNA that has been […]
Summary: a DNA methylation age inference method, combined with Sequenom MassARRAY technology, can reduce the error of the age to 4.7 years. Age estimation is one of the most important topics in the field of forensic medicine. Especially for juvenile delinquency, highly corrupt bones of the dead and nameless corpse, it can provide the scope […]
Whole exome sequencing (WES) is now being used more and more in the field of research and diagnosis. Researchers are expected to study the entire coding regions of known genes with adequate sequencing depth and coverage. Currently a large number of exome capture platforms on the market have there respective advantages and some differences in […]
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