2020 | CD Genomics Blog

Why Do We Study lncRNA? The Formerly Regarded “Transcriptional Junk” Sheds Light on Disease Research

December 25, 2020

Determining an appropriate treatment through precision medicine requires inspection of crucial novel biomarkers from tissue samples or liquid biopsies such as plasma/serum, sputum, saliva, urine, and cerebrospinal fluid for earlier disease diagnosis and prognosis. Analysis of non-coding RNA such as microRNA (miRNA) and long noncoding RNA (lncRNA), DNA methylation, and posttranslational histone modifications are epigenetic […]

CRISPR Screen Sequencing, An Innovative Sequencing Technology that Can Facilitate COVID-19 Research

November 20, 2020

Clustered regularly interspaced short palindromic repeats, or CRISPR, is one of the most phenomenal discoveries that paved the way for modern genome screening and editing technologies. CRISPR is a family of DNA found in the genome of prokaryotes, specifically bacteria and archaea. These sequences contain DNA fragments from known bacteriophages that infect the particular prokaryote. […]

Virus Sequencing, A Handy Method to Facilitate Hepatitis C Virus Research

October 27, 2020

The Discovery of Hepatitis C Virus Hepatitis, or the inflammation of the liver, is primarily caused by viral infection. Other significant factors to it include alcohol abuse, environmental contaminants, and autoimmune diseases. It became apparent in the 1940s that there were two major forms of contagious hepatitis. In the 1960s, Hepatitis B and A vaccines […]

RIP-Seq vs. CLIP-Seq: Introduction, Advantages, and Applications

September 29, 2020

The protein translation is a complicated process. In the past decades, scientists have focused mainly on the interpretation of the coding region of a gene, which can directly determine the amino acid composition of a protein. Recently, research on the non-coding RNA (ncRNA) regions have greatly interested the scientists and large amount of evidence indicates […]

DNA Microarray vs. High-Throughput Sequencing: A Brief View and the Applications in Gut Microbiome Research

August 19, 2020

With the advent of the post-genome era, gene chip and next-generation sequencing have become two important branches of biochemistry and molecular biology technologies. DNA microarray, also known as gene chip, is a method characterized by high throughput, high efficiency, and high automation. In a gene chip array, a large number of known probe sequences are […]

Comprehensive and Quantitative Profiling of Translation – Ribo-Seq and Application in Virology

July 22, 2020

In the past decade, second-generation sequencing has been rapidly developed and widely used in the studies of genome, transcriptome, and epigenetics of many species. It also acts as an important technological support for pharmacy, diagnosis, and many other fields. In recent years, second-generation sequencing has been increasingly used to monitor protein translation. Combining ribosome profiling […]

Applications of Single-Cell Sequencing Technology in Microbial Ecology

June 28, 2020

Microbial ecology is the study of the relationships of microorganisms with one another and with their environment. Microbial diversity, distribution, abundance, specific interactions, and their impact on ecosystems are explored. Elected by the scientific journal Nature as one of the technologies to watch for in 2020, single-cell sequencing is a rising technology in single-cell ecology. […]

Transcriptome Sequencing: Introduction, Advantages, and Applications

June 8, 2020

The transcriptome is the collection of all RNA transcribed by an individual or a population of cells at a certain biological state. The studies into transcriptome focus on mRNAs and non-coding RNAs (ncRNAs), which encode various proteins and act as cellular regulators respectively. Transcriptomic studies interpret gene function and gene structure in a holistic view, […]

Virus Sequencing: Technologies, Features, and Significance in Outbreaks

May 4, 2020

Emerging infectious diseases have the potential to impose enormous mortality, morbidity, and economic burdens on humans. Tracking the spread of infectious diseases to help control them has traditionally relied on the analysis of case data collected during the course of an epidemic or pandemic. Over the last few decades, there has been a few cases […]

DNA Sequencing: Definition, Methods, and Applications

April 2, 2020

What Is DNA Sequencing? DNA sequencing refers to the method employed to determine the order of the four nucleotide bases—adenine, thymine, cytosine, and guanine—that constitute a DNA molecule and convey critical genetic information. Within the DNA double helix, these four bases pair with specific partners to form units known as base pairs (bp): adenine (A) with […]

Yearly Archives: 2020