Overview of whole genome sequencing

Whole genome sequencing (WGS) provides a complete analysis of the entire DNA sequence of the entire genome, including DNA in the nucleus, chloroplasts and mitochondria. whole genome sequencing has a broad coverage, enabling a full range of genetic data to be analyzed at the individual or population level. NGS-based whole genome sequencing can identify and characterize changes in genetic material such as insertions and deletions (indels), copy number variants (CNVs), structural variants (SVs), single nucleotide polymorphisms (SNPs), and other variants of the genome with high accuracy. The results of the above comprehensive genome-wide analyses will help advance the mechanistic studies of hereditary diseases, mutational characterization of cancers and exploration of other mutation-related diseases. Further, whole genome sequencing can help to participate in the study of relevant drug targets and markers.

The workflow of whole genome sequencing

Here, CD Genomics provides you with high-throughput and accurate NGS-based whole genome sequencing services. Each of these steps is executed by our experienced experts under strict quality control and program settings. As shown in the diagram below, our workflow of whole genome sequencing consists of the following main parts.

01. Sequencing sample requirements

02. Library construction and NGS

Low-cost and high-accuracy Illumina / MGI NGS platform

03. Bioinformatics Analysis

• Genome-wide profiling and genetic analysis
• Gene annotation and statistics
• Evaluation of sequencing depth and coverage
• Pathway enrichment analysis
• Identification and characterization of insertions and deletions (indels), copy number variants (CNVs), structural variants (SVs), single nucleotide polymorphisms (SNPs)
• Population genetics analysis

Advantages of our whole genome sequencing service

• Low cost but high coverage and high depth whole genome sequencing
• High-resolution base-by-base analysis and identification
• Identifies potential causative variants for further follow-up studies of gene expression and regulation mechanisms
• Strict quality control based on professional and standardized sequencing processes

Applications in pharma research

CD Genomics provides accurate and comprehensive NGS-based whole-genome sequencing, such as cancer whole-genome sequencing, microbial whole-genome sequencing, rare disease whole-genome sequencing and complex disease sequencing. CD Genomics will ultimately provide detailed bioinformatics results to assist in the analysis of unique mutations in cancer tissues, genetic disease risk reference, genomic characterization of novel viruses, and complex disease mechanisms. Our whole genome sequencing can be applied to the biopharmaceutical field, providing new ideas and directions for disease and related new drugs, like the discovery of biomarkers and new targets. We are always committed to advancing the drug discovery process of pharmaceutical companies through highly accurate and cost-effective whole-genome sequencing in the following aspects.

CD Genomics is dedicated to combining professional project protocol guidance and standardized analysis processes to ensure that your project is performed accurately and quickly. If you are interested in CD Genomics' whole genome sequencing services in the field of pharma research, please feel free to contact us now.