The coding region consists of exons and introns. Exons belong to the protein-coding region of the genome and make up only 1-2% of the human genome. However, up to 85% of the disease-associated mutations associated with Mendelian diseases occur in these regions. Although whole-exome sequencing has a smaller detection area than whole-genome sequencing, it is easier to achieve high-depth sequencing. Whole-exome sequencing can detect more low-frequency and rare variants, as well as reduce the cost and storage space for testing.
Figure 1. The distribution of coding and non-coding regions on the gene and the location of exons in the coding region are shown.
CD Genomics can provide you with NGS-based whole-exome sequencing services to support you in performing more in-depth biomarker analysis related to genetic information. With our experienced team of experts and best-in-class sequencing technology platform to ensure that the entire sequencing process is performed under strict QC standards, the sequencing reports you receive from CD Genomics are sure to be the most comprehensive and reliable.
CD Genomics has always been committed to inspiring your ideas and ideas for biomarker research through high quality exome sequencing services. We offer a one-stop efficient exome sequencing service where you only need to provide test samples and will receive a comprehensive or customized bioinformatics analysis report in the shortest turnaround time. The sequencing process is shown below, where each step is carefully designed according to high scientific standards.
01. Sequencing sample requirements
| Sample Type | DNA Amount | DNA Concentration | Purity |
|---|---|---|---|
| Total DNA from cells, blood, saliva, tissue, formalin-fixed samples, fresh frozen tissue samples, paraffin-embedded tissues, cancer liquid biopsies, etc. | ≥ 200 ng | ≥20 ng/μL | OD260/280=1.8 - 2.0; no degradation, no contamination |
02. Library construction and NGS
03. Bioinformatics Analysis
Genomic biomarkers are important tools for cancer and disease diagnosis, treatment prescription and monitoring of patient outcomes. CD Genomics is dedicated to deep sequencing of protein coding regions, providing more detailed exome sequencing and analytical comparative data to support researchers in biomarker discovery for a wide range of diseases. CD Genomics' exome sequencing services are primarily used in the development of biomarkers for various CD Genomics' exome sequencing services are used in the development of biomarkers for a wide range of diseases, early detection of disease, and drug development processes.
CD Genomics is committed to combining professional project protocol guidance and standardized analysis processes to ensure that your project is performed accurately and quickly. If you are interested in CD Genomics' whole exome sequencing services in the biomarker discovery research, please feel free to contact us now.
CD Genomics is transforming biomedical potential into precision insights through seamless sequencing and advanced bioinformatics.
