Overview of cancer panel sequencing

Fundamentally, cancer is a malignant disease that arises from DNA mutations, with foci that eventually lead to uncontrolled cell division due to altered gene expression patterns. CD Genomics can provide you with cancer panel sequencing services and detailed bioinformatics analysis. Cancer panels are panels that allow for pre-designed and customized targeted sequencing analysis based on Illumina and MGI technologies, enabling more comprehensive cancer genetic testing. NGS-based targeted sequencing allows genetic analysis for specific tumor mutation profiles, which can provide solutions for precision cancer treatment. In addition, cancer panels can also enable microsatellite instability (MSI) and tumor mutation burden (TMB) status detection for immuno-oncology studies. Our cancer panels cover the full exonic regions of a total of 516 genes associated with most tumors. Please refer to Cancer Panel Sequencing Gene List for more information of CD Genomics' cancer panel sequencing genes.

Cancer panel sequencing workflow

Based on high-performance, highly sensitive and high-throughput targeted NGS sequencing technology, CD Genomics can provide you with a variety of designed and customized cancer panel sequencing services for more efficient and accurate targeting of specific genes or mutations. Our professional team of experts can strictly enforce quality control requirements and follow standard procedures to ensure the authenticity and reliability of the reported results of sequencing analysis. You can see the workflow of cancer panel sequencing shown below.

01. Sample requirements

02. Library construction and NGS

Amplicon sequencing for evaluation of somatic alterations within the listed genes based on Illumina and MGI

03. Bioinformatics Analysis

• Annotation of somatic cell tumor-associated gene mutation types such as single nucleotide variants, small deletions, insertions, gene amplifications, splice variants, etc.
• Quantitative values of TMB and qualitative assessment of MSI (MSS, MSI-H).
• Other data analysis requirements according to your needs.

Advantages of our cancer panel sequencing services

• Illumina and MGI can cost-effectively achieve high sequencing depth with low sample volumes for cancer panel sequencing.
• The samples to be tested can be of a broad range of DNA sources, such as blood samples, cells, tissues (FFPE), etc.
• Strict quality control is maintained throughout the efficient and automated workflow for accurate and reliable sequencing analysis results.
• High coverage and uniform sequencing of cancer-related genes ensures comprehensive and detailed analysis results.

Applications in immuno-oncology research

The high-throughput and high-sensitivity NGS-based cancer panel sequencing service from CD Genomics has applications covering most major tumor types, targeting all of the more commonly cited and more frequently mutated exons of key tumor suppressor genes and oncogenes. Cancer panel sequencing can be applied mainly in the following directions of tumor immunology research.

CD Genomics is committed to combining professional project protocol guidance and standardized analysis processes to ensure that your project is performed accurately and quickly. If you are interested in CD Genomics' cancer panel sequencing workflow in the field of immuno-oncology, please feel free to contact us now.